Luis Colón, 1st Duke of Veragua first son of Diego Colón and María Álvarez de Toledo y Rojas, and grandson of Christopher Columbus. (1522–1572) Parents Diego Columbus María de Toledo Children Felipa Colón de Toledo, 3rd duchess of Veragua Siblings María Colón de la Cueva Don Christobál Colón de Toledo, Caballero de Alcántara Doña Isabel de Colón de Toledo Doña Juana de Colón de Toledo