Maria of Aragon queen of Portugal (1482–1517) Parents Isabella I of Castile Ferdinand II of Aragon Children Isabella of Portugal Infante Edward, 4th Duke of Guimarães John III of Portugal Cardinal-Infante Afonso of Portugal Beatrice of Portugal, Duchess of Savoy Henry I of Portugal Luís of Portugal, Duke of Beja Maria of Portugal Infante Ferdinand, Duke of Guarda and Trancoso Siblings John, Prince of Asturias Isabel of Aragon Catherine of Aragon Alonso de Estrada John of Aragon, Prince of Girona Juana I of Castile Alonso de Aragón Juana de Aragón Ruiz de Ivorra María Esperanza de Aragón Partners Manuel I of Portugal
