Charles V Holy Roman Emperor from 1519 to 1556 (1500–1558) (1500–1558) Parents Juana I of Castile Philip I of Castile Margaret of Austria, Duchess of Savoy Children Margaret of Parma Philip II of Spain Maria of Austria, Holy Roman Empress Isabel of Castile John of Austria Juana de Austria y Xériga Juan Austria y Portugal Infante Fernando of Austria Joanna of Austria, Princess of Portugal Tadea of Austria Siblings Eleanor of Austria Isabella of Austria Catherine of Austria, Queen of Portugal Mary of Hungary Ferdinand I, Holy Roman Emperor Partners Germaine of Foix Johanna Maria van der Gheynst Orsolina della Penna Barbara Blomberg Isabella of Portugal
