Catherine of Austria, Queen of Portugal queen consort and regent of Portugal (1507–1578) Parents Juana I of Castile Philip I of Castile Children Philip, Prince of Portugal António, Infante de Portugal Manuel, Prince of Portugal Maria Manuela, Princess of Portugal Afonso, Prince of Portugal João Manuel, Prince of Portugal Siblings Eleanor of Austria Isabella of Austria Charles V Mary of Hungary Ferdinand I, Holy Roman Emperor Partners John III of Portugal
